WHAT IS IT?
Inovio's inducible gene regulation system, the GeneSwitch® system, controls gene expression through an orally administered drug. Our extended portfolio of gene expression components also includes tissue-specific promoters and multi-gene cassettes. We are developing the GeneSwitch® system as a plasmid-based (non-viral) system to regulate expression of systemic proteins from the muscle for therapeutic purposes.
Potential applications for this gene regulation system include functional genomics and gene therapy. The GeneSwitch® system has been used to provide ligand-dependent transgene expression in transfected mammalian cells, in transgenic animals, and in preclinical gene therapy studies with viral and non-viral gene delivery systems.
WHO CAN USE IT?
The GeneSwitch® gene regulation system is available for licensing as a functional genomics research tool. To date, various corporate partners have obtained licenses to the technology for commercial research purposes, utilizing the technology as a platform tool in gene function and drug target discovery. Corporate partners who have licensed the GeneSwitch® system include:
- Lexicon Genetics
- Medigene A.G.