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Pre-1999 Archives

GeneSwitch® papers

Oligino, T., Poliani, P.L., Wang, Y., Tsai, S.Y., O’Malley, B.W., Fink, D.J. and Glorioso, J.C. (1998). Drug inducible transgene expression in brain using a herpes simplex virus vector. Gene Ther. 5, 491-496. - Describes first herpes simplex virus vector GeneSwitch® system (version 1.0) and its use in brain.

Wang, Y., DeMayo, F.J., Tsai, S.Y. and O’Malley, B.W. (1997). Ligand-inducible and liver-specific target gene expression in transgenic mice. Nature Biotech. 15, 239-243. - First application of the GeneSwitch® system (version 1.0) in transgenic mice.

Wang, Y., Xu, J., Peirson, T., O’Malley, B.W. and Tsai, S.Y. (1997). Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator. Gene Ther. 4, 432-441. - Describes the improved GeneSwitch® system (version 2.0) and the negative GeneSwitch® system.

Wang, Y., O’Malley, B.W., Jr., Tsai, S.Y. and O’Malley, B.W. (1994). A regulatory system for use in gene transfer. Proc. Natl. Acad. Sci. USA 91, 8180-8184. - Description of the original GeneSwitch® system (version 1.0).

Review articles

Tsai, S.Y., O'Malley, B.W., DeMayo, F.J., Wang, Y. and Chua, S.S. (1998). A novel RU486 inducible system for the activation and repression of genes. Adv. Drug Deliv. Rev. 30(1-3), 23-31.

Burcin, M.M., O'Malley, B.W. and Tsai, S.Y. (1998). A regulatory system for target gene expression. Front Biosci. 3, c1-7.

Allgood, V.E. and Eastman, E.M. (1997). Chimeric receptors as gene switches. Curr. Opin. in Biotech. 8, 474-479.

Allgood, V.E. and Eastman, E.M. (1997). Novel gene switches for the regulation of gene expression. Annual Reports in Med. Chem. (Acad. Press) Chapter 32, 231-239.

GeneSwitch® - related papers

Vegeto,E., Allan, G.F., Schrader, W.T., Tsai, M.J., McDonnell, D.P. and O'Malley, B.W. (1992). The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell 69(4), 703-713. - Identification of the mutant progesterone receptor ligand-binding domain.

Schmitz, M.L. and Baeuerle, P.A. (1991). The p65 subunit is responsible for the strong transcription activating potential of NF-kB. EMBO J. 10(12), 3805-3817. - Identification of the p65 activation domain of NF-kB.

Ginger, E. and Ptashne, M. (1988). Cooperative DNA binding of the yeast transcriptional activator GAL4. Proc. Natl. Acad. Sci. USA 85, 382-386. - Describes the interaction of the GAL4 DNA binding domain with its target sequence.

Ginger, E., Varnum, S.M. and Ptashne, M. (1985). Specific DNA binding of GAL4, a positive regulatory protein of yeast. Cell 40(4), 767-774. - Indentification of the GAL4 DNA binding protein.

Triezenberg, S. J., Kingsbury, R.C. and McKnight, S.L. (1988). Functional dissection of VP16, the transactivator of herpes simplex virus immediate early gene expression.  Genes Dev. 2, 718-729. - Identification of the VP16 activation domain.